OSU is at home in a big time rivalry game. OSU IS ranked #12. They've only been beat by Texas and Tech. This game isn't going to be the roll over OU just had in Tech. OSU needs their statement game this year and desperately wants to win this game.
Of all the high ranking teams including Florida, OU, and Alabama, OSU stands the perhaps the best chance at an upset. But I wouldn't bet the farm on that.